RepSox
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Cat. No.
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: NU03036
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Synonyms
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: 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
E-616452
SNJ 2511
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CAS No.
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: 446859-33-2
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Formula
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: C17H13N5 (287.3)
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Appearance
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: Pale-yellow powder
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Purity
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: 98% or more (HPLC), NMR (Conforms)
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Solubilization
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: May be dissolved in DMSO (25 mg/ml); or Ethanol (10 mg/ml)
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Storage
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: Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 1 month.
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Pharmacology
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: RepSox is a potent inhibitor of the TGF-β type I receptor (ALK5), IC50 ALK5 auto-P= 4 nM and IC50 TGF-β cellular assay = 23 nM1. RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog ranscription2,3. It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021)4,5.
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References
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: 1. F Gellibert et al. J. Med. Chem. 2004 47:4494 2. JK Ichida et al. Cell Stem Cell 2009 5:491 3. W Li et al. Cell Stem Cell 2009 4:16 / L Cheng et al. Cell Res. 2015 25:1269 4. L Cheng et al. Cell Res. 2014 24:665 |
Ordering Information
Small Molecules for Stem Cell Research
| Product | CAS No. | Purity | Storage | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|---|---|
| RepSox | 446859-33-2 | 98% (HPLC) | Room Temp. | NU03036 | 10 mg | 140.00 | Buy |