SB431542
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Cat. No.
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: NU03031
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Synonyms
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: 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
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CAS No.
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: 301836-41-9
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Formula
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: C22H16N4O3 (384.4)
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Appearance
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: Yellow powder
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Purity
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: 98% or more (HPLC), NMR (Conforms)
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Solubilization
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: May be dissolved in DMSO (30 mg/ml); or ethanol (3 mg/ml)
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Storage
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: Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 3 months.
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Pharmacology
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: Potent and selective ALK4, ALK5 and ALK7 inhibitor (TGFβ superfamily Type I activin receptor-like kinase). (ALK5 IC50 = 94 nM)1,2. Inhibits TGFβ -induced proliferation of human osteosarcoma cells3. Enhances growth and integrity of embryonic
stem cell-derived endothelial cells4. A frequently used agent employed in numerous stem cell differentiation protocols5. Cell permeable. |
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References
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: 1. NJ Laping et al. Mol. Pharmacol. 2002 62:58 2. GJ Inman et al. Mol. Pharmacol. 2002 62:65 3. S Matsuyama et al. Cancer Res. 2003 63:7791 4. T Watabe et al. J. Cell Biol. 2003 163:1303 5. N Stanslowsky et al. Stem Cell Res. Ther. 2014 5:35 |
Ordering Information
Small Molecules for Stem Cell Research
| Product | CAS No. | Purity | Storage | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|---|---|
| SB431542 | 301836-41-9 | 98% (HPLC) | Room Temp. | NU03031 | 10 mg | 110.00 | Buy |