XAV-939
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Cat. No.
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: NU09018
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Synonyms
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: 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol
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CAS No.
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: 284028-89-3
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Formula
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: C14H11F3N2OS (312.3)
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Appearance
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: Off-white powder
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Purity
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: 98% or more (HPLC), NMR (Conforms)
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Solubilization
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: May be dissolved in DMSO (25 mg/ml)
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Storage
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: Store as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 2 months.
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Pharmacology
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: Tankyrase inhibitor (IC50=11 and 4 nM for TNKS1 and 2 respectively). Antagonizes Wnt signaling downstream of receptor activation via stabilization of axin, a negative regulator of β-catenin1. Robustly induces cardiomyogenesis of stem cells2.
Reduces experimental fibrosis in a mouse model of bleomycin-induced dermal fibrosis3. Promotes apoptosis in a neuroblastoma cell line via telomere shortening4. An important tool for probing the activation of the Wnt/β-catenin pathway in cells5. Cell permeable. |
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References
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: 1. S. Huang et al. Nature 2009 46:614 2. H Wang et al. ACS Chem. Biol. 2011 6:192 3. A Distler Wang et al. Ann. Rheum. Dis. 2013 72:1575 4. X Tian et al. Oncol. Rep. 2014 32:1999 5. KC Davidson et al. Proc. Natl. Acad. Sci. USA 2012 109:4485 |
Ordering Information
Small Molecules for Stem Cell Research
| Product | CAS No. | Purity | Storage | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|---|---|
| XAV 939 | 284028-89-3 | 98% (HPLC) | Room Temp. | NU09018 | 10 mg | 90.00 | Buy |