A83-01
|
Cat. No.
|
: NU09014
|
|
Synonyms
|
: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
|
|
CAS No.
|
: 909910-43-6
|
|
Formula
|
: C25H19N5S (421.5)
|
|
Appearance
|
: Pale-yellow powder
|
|
Purity
|
: 98% or more (HPLC), NMR (Conforms)
|
|
Solubilization
|
: May be dissolved in DMSO (20 mg/ml)
|
|
Storage
|
: Store desiccated as supplied at -20°C for up to 3 years. Store solutions at -20°C for up to 2 months.
|
|
Pharmacology
|
: Potent and selective ALK4, 5 and 7 inhibitor1,2. IC50=45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ2. Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency3. Together with AMI-5, A83-01 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts4. Cell permeable. Active in vivo.
|
|
References
|
: 1. J Vogt et al. Cell Signal. 2011 23:1831
2. M Tojo et al. Cancer Sci. 2012 96:791
3. W Li et al. Cell Stem Cell 2009 4:16
4. X Yuan et al. Stem Cells 2011 29:549
|
Ordering Information
Small Molecules for Stem Cell Research
| Product | CAS No. | Purity | Storage | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|---|---|
| A 83-01 | 909910-43-6 | 99% (HPLC) | -20°C | NU09014 | 10 mg | 105.00 | Buy |