Rosiglitazone
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Cat. No.
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: NU03034
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Synonyms
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: 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
BRL-49653
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CAS No.
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: 122320-73-4 |
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Formula
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: C18H19N3O3S (357.4) |
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Appearance
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: White powder |
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Purity
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: 98% or more (TLC/HPLC), NMR (Conforms) |
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Solubilization
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: May be dissolved in DMSO (50 mg/ml); or DMF (40 mg/ml) |
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Storage
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: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months. |
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Pharmacology
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: Prototypical TZD antidiabetic agent. Potent and selective PPARγ agonist (Kd=43 nM)1,2. Clinically useful antihyperglycemc agent3. Induces a brown fat gene program in subcutaneous white adipose tissue via activation of the PRDM16 protein4.
Induces differentiation of pluripotent stem cells into adipocytes5. |
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References
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: 1. BC Cantello et al. J. Med. Chem. 1994 37:3977 2. JM Lehmann et al. J. Biol. Chem. 1995 270:12953 3. TM Wilson et al. J. Med. Chem. 1996 39:665 4. O Haruya et al. Cell Metab. 2012 15:395 5. DJ Ruiz-Ojeda et al. Int. J. Mol. Sci. 2016 17:1040 |
Ordering Information
Small Molecules for Stem Cell Research
| Product | CAS No. | Purity | Storage | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|---|---|
| Rosiglitazone | 122320-73-4 | 98% (TLC/HPLC) | -20°C | NU03034 | 10 mg | 68.00 | Buy |