PD-325901
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Cat. No.
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: NU03033
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Synonyms
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: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide
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CAS No.
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: 391210-10-9
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Formula
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: C16H14F3IN2O4 (482.2)
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Appearance
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: White powder
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Purity
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: 98% or more (HPLC), NMR (Conforms)
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Solubilization
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: May be dissolved in DMSO (12 mg/ml)
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Storage
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: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
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Pharmacology
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: A selective non-ATP competitive MEK inhibitor (IC50 = 0.33 nM)1. Inhibits growth and/or proliferation of a variety of cancer cells2. Enhances self-renewal of embryonic stem cells3. In combination with vitamin C, synergistically induces hypomethylation of mouse embryonic stem cells4. In combination with CHIR-99021 and A83-01 induces generation of ground state iPS cells from human and rat somatic cells5.
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References
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: 1. SD Barrett et al. Bioorg. Med. Chem. Lett. 2008 18:6501 2. L Ciuffreda et al. Neoplasia 2009 11:720 3. Z Ai et al. Stem Cells Int. 2016 2016:1792573 4. C Li et al. Oncotarget 2016 7:39730 5. W Li et al. Cell Stem Cell 2009 4:16 |
Ordering Information
Small Molecules for Stem Cell Research
| Product | CAS No. | Purity | Storage | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|---|---|
| PD-325901 | 391210-10-9 | 98% (HPLC) | -20°C | NU03033 | 10 mg | 110.00 | Buy |