Forskolin
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Cat. No.
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: NU03029
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Synonyms
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: 7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one
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CAS No.
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: 66575-29-9
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Formula
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: C22H34O7 (410.5)
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Appearance
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: White powder
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Purity
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: 99% or more (HPLC), NMR (Conforms)
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Solubilization
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: May be dissolved in DMSO (10 mg/ml); or ethanol (4 mg/ml). Note, DMSO is the solvent of choice in experimental protocols for adenylate cyclase activation. Do not use ethanol which inhibits forskolin-stimulated adenylate cyclase.
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Storage
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: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 4 months.
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Pharmacology
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: Extremely useful activator of adenylate cyclase (EC50=2-10 µM)1,2. A hypotensive, vasodilatory and positive inotropic agent3. Induces stem cell neuronal differentiation4. Cell permeable and active in vivo.
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References
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: 1. PA Insel and RS Ostrom Cell Mol. Neurobiol. 2003 23:305 2. A Laurenza et al. Trends Pharmacol. Sci. 1989 10:442 3. NJ De Souza Med. Res. Rev. 1983 3:201 4. SS Kim et al. Neuroreport 2005 16:1357 |
