trans-ISRIB
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Cat. No.
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: NU03040
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Synonyms
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: N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]; trans-ISRIB
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CAS No.
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: 1597403-47-8
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Formula
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: C22H24NCl2N2O4 (451.3)
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Appearance
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: White powder
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Purity
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: 98% or more (TLC), NMR (Conforms)
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Solubilization
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: May be dissolved in DMSO (5 mg/ml, warm)
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Storage
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: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months.
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Pharmacology
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: Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM1. Enhances spatial and fear-associated learning in mice and enhances cognitive function1,2. Mechanism of action involves activation of eiF2β3. Suppresses ER stress-induced inflammatory gene expression4. Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production5. Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models6.
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References
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: 1. C Sidrauski et al. Elife 2013 2:e00498 2. Y Sekine et al. Science 2015 348:1027 3. C Sidrauski et al. Elife 2015 4:e07314 4. LN Guthrie et al. J. Biol. Chem. 2016 291:15830 5. T Hosoi et al. J. Pharmacol. Sci. 2016 131:292 6. A Chou et al. Proc. Natl. Acad. Sci. USA 2017 114:E6420 |
Ordering Information
Small Molecules for Stem Cell Research
| Product | CAS No. | Purity | Storage | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|---|---|
| trans-ISRIB | 1597403-47-8 | 98% (TLC) | -20°C | NU03040 | 5 mg | 89.00 | Buy |