IWR-1-endo
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Cat. No.
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: NU03035 |
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Synonyms
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: 4-(1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl)-N-8-quinolinylbenzamide |
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CAS No.
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: 1127442-82-3 |
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Formula
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: C25H19N3O3 (409.4) |
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Appearance
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: Off-white to yellow powder |
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Purity
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: 98% or more (TLC/HPLC), NMR (Conforms) |
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Solubilization
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: May be dissolved in DMSO (10 mg/ml) |
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Storage
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: Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months. |
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Pharmacology
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: A potent inhibitor of Wnt signaling (IC50=180 nM)1. Inhibits zebrafish tailfin regeneration (0.5 µM)2. Acts via inhibition of tankyrase and attenuates wnt/β-catenin signaling in cancer stem-like cells3. Promotes self-renewal and maintains pluripotency of human embryonic stem cells4. Promotes differentiation of pluripotent stem cells into cardiomyocytes5. |
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References
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: 1. B Chen et al. Nature Chem. Biol. 2009 5:100 2. J Lu et al. Biorg. Med. Chem. Lett. 2009 19:3825 3. SR Martins-Neves et al. Cancer Lett. 2018 414:1 4. H Kim et al. Nature Commun. 2013 4:3403 5. Y Ren et al. J. Mol. Cell. Cardiol. 2011 51:280 |
Ordering Information
Small Molecules for Stem Cell Research
| Product | CAS No. | Purity | Storage | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|---|---|
| IWR-1-endo | 1127442-82-3 | 98% (TLC/HPLC) | -20°C | NU03035 | 10 mg | 110.00 | Buy |