IBMX
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Cat. No.
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: NU03039
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Synonyms
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: 3-Isobutyl-1-methylxanthine
3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
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CAS No.
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: 28822-58-4
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Formula
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: C10H14N4O2 (222.3)
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Appearance
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: White powder
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Purity
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: 99% or more (TLC), NMR (Conforms)
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Solubilization
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: May be dissolved in DMSO (15 mg/ml); or ethanol (10 mg/ml)
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Storage
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: Store desiccated as supplied at ambient temperature for up to 2 years. Store solutions at -20°C for up to 3 months.
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Pharmacology
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: Pan-specific inhibitor of phosphodiesterases (IC50=2-50 µM)1. Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA2. Does not inhibit PDE8 or PDE93. Weak adenosine receptor antagonist4.
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References
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: 1. JA Beavo et al. Mol. Pharmacol. 1970 6:597 2. C Tomes et al. Cell. Signal. 1993 5:615 3. SH Soderling et al. Curr. Opin. Cell Biol. 2000 12:174 4. JW Daly et al. Prog. Clin. Biol. Res. 1987 230:41 |
