Under accelerated pH 10.4, 40°C stability test, COSMOCORE C₁₈ column shows superior stability compared with other core shell C₁₈ phases.

COSMOCORE 2.6C₁₈ maintains the same performance as sub-2 µm particles with half the back pressure.

COSMOCORE 2.6C₁₈ delivers performance equivalent to sub-2 µm particles at faster flow rate and analysis time while maintaining a lower back pressure. COSMOCORE can also be used in longer column size to gain additional resolution.

• Retention
  COSMOCORE 2.6C₁₈ features high retention and better separation compared to other core-shell columns

• Higher Loading Capacity
  In general, core-shell particles have less surface area and less bonded phase than fully porous particles. COSMOCORE 2.6C₁₈, however, with a large amount of bonded phase, exhibits both high retention and high loading capacity. When injecting 5-10 times more sample volumes in the trace component analysis, COSMOCORE minimizes peak splitting due to the sample over loading.

COSMOCORE 2.6C₁₈ has low column bleed, and consequently low MS noise level.

COSMOCORE 2.6C₁₈ exhibits high durability. There is no significant deterioration in retention or peak shape after 1,000 injection of amitriptyline.

COSMOCORE 2.6C₁₈ features a special endcapping treatment that effectively shields residual silanol groups, yielding sharp peaks for basic compounds and metal coordination complexes.

Oligonucleotide research has exploded in recent years, requiring new and sophisticated techniques not only in their application, but also analysis. Phosphorothioate modification of oligonucleotides (S-oligos) is a technique used to improve stability and slow degradation by nucleases. In the synthesis of S-oligos it is imperative that modifications are as directed, whether it be a partially or fully modified S-oligo. COSMOCORE 2.6C₁₈ columns are shown here in a method to elucidate minute differences in chemical modification with excellent resolution.

Figure 1: Overlaid chromatograms of fully and partially phosphorothioated DNA oligos. Excellent resolution is observed between oligos of the same length and differing number of modifications.

COSMOSIL Application, which includes more than 7,700 applications using COSMOSIL/COSMOCORE columns, is now usable by clicking the link below which is in Nacalai Tesque, Inc. The application is searchable by sample category, sample name, CAS No., column name and particle size