COSMOSIL C18-MS-II
Reversed Phase / Monomeric C18
COSMOSIL 5C18-MS-II is a monomeric type of C18 phase. A new endcapping treatment with polar groups for "shield effect" has extended the pH range and significantly improved peak shape for basic compounds. This phase is recommended for most of applications but particularly effective for low molecular weight organic compounds.
| COSMOSIL C18-MS-II | ||
|---|---|---|
| USP code | L1 | |
| Silica gel | High purity porous spherical silica | |
| Average particle size | 2.5 µm | 3 µm, 5 µm, 15 µm |
| Average pore size | approx. 130Å | approx. 120Å |
| Specific surface area | approx. 330m2/g | approx. 300m2/g |
| Stationary phase | Octadecyl group | Octadecyl group |
| Bonding Type | Monomeric type | Monomeric type |
| End capping treatment | Near-perfect treatment | Near-perfect treatment |
| Carbon content | approx. 18% | approx. 16% |
| pH range | 2 - 10 | 2 - 10 |
Stability under alkaline condition
Column: COSMOSIL 5C18-MS-II 4.6 x 150 mm
Application for nitrosamine analysis
Application for nitrosamine analysis
Nitrosamines are a group of compounds that result from various pharmaceutical synthesis processes, especially amine reactions. They are potential carcinogens and genotoxins, and their unexpected presence in drugs has been the cause of some recalls and resulting drug shortages.
We have developed a chromatographic method which separates 8 nitrosamines on our 5C18-MS-2 column. This enables detection and quantification of these compounds of concern.
Application
COSMOSIL Application Search
COSMOSIL Application, which includes more than 7,700 applications using COSMOSIL/COSMOCORE columns, is now usable by clicking the link below which is in Nacalai Tesque, Inc. The application is searchable by sample category, sample name, CAS No., column name and particle size
Ordering Information
Guard Column / Guard Cartridge
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 5C18-MS-II Guard Column (2.0 mm I.D. x 10 mm) | End-Fitting: Waters type | 06097-51 | 1 pkg | - | Inquire |
HPLC Accessories
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL Column Spare Filter for Prefilter (1 micron) | End-Fitting: Waters type | 39539-09 | 2 pkg | 55.00 | Buy |
| COSMOSIL Column Connecting Tube (0.25 mm) | End-Fitting: Waters type | 37843-69 | 1 pkg | 65.00 | Buy |
| COSMOSIL Column Connecting Tube (0.1 mm) | End-Fitting: Waters type | 12570-41 | 1 pkg | 65.00 | Buy |
| COSMOSIL Column Prefilter | End-Fitting: Waters type | 39361-19 | 1 pkg | 145.00 | Buy |
Guard Column / Guard Cartridge
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 3C18-MS-II Guard Cartridge (4.6 mm I.D. x 10 mm) | End-Fitting: Waters type | 21234-84 | 2 pkg | 188.00 | Buy |
| COSMOSIL 5C18-MS-II Guard Cartridge (4.6 mm I.D. x 10 mm) | End-Fitting: Waters type | 38015-89 | 3 pkg | 188.00 | Buy |
HPLC Accessories
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL Guard Cartridge Holder (2.0 mm I.D.) | End-Fitting: Waters type | 11884-71 | 1 pkg | 265.00 | Buy |
| COSMOSIL Direct Cartridge Holder | End-Fitting: Waters type | 19989-71 | 1 pkg | 270.00 | Buy |
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 3C18-MS-II Packed Column (4.6 mm l.D. x 10 mm) | End-Fitting: Waters type | 38065-71 | 1 pkg | 359.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (4.6 mm l.D. x 50 mm) | End-Fitting: Waters type | 38066-61 | 1 pkg | 359.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (4.6 mm I.D. x 30 mm) | End-Fitting: Waters type | 34341-61 | 1 pkg | 386.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (4.6 mm I.D. x 50 mm) | End-Fitting: Waters type | 38017-01 | 1 pkg | 386.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (3.0 mm l.D. x 100 mm) | End-Fitting: Waters type | 34366-51 | 1 pkg | 450.00 | Buy |
Guard Column / Guard Cartridge
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 5C18-MS-II Guard Column (10.0 mm I.D. x 20 mm) | End-Fitting: Waters type | 38016-11 | 1 pkg | 450.00 | Buy |
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 5C18-MS-II Packed Column (4.6 mm I.D. x 100 mm) | End-Fitting: Waters type | 38018-91 | 1 pkg | 471.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (4.6 mm I.D. x 150 mm) | End-Fitting: Waters type | 38019-81 | 1 pkg | 471.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (2.0 mm l.D. x 75 mm) | End-Fitting: Waters type | 34470-71 | 1 pkg | 482.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (3.0 mm l.D. x 150 mm) | End-Fitting: Waters type | 07267-91 | 1 pkg | 482.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (1.0 mm I.D. x 50 mm) | End-Fitting: Waters type | 02824-31 | 1 pkg | 482.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (2.0 mm I.D. x 30 mm) | End-Fitting: Waters type | 05876-71 | 1 pkg | 482.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (2.0 mm I.D. x 50 mm) | End-Fitting: Waters type | 04355-21 | 1 pkg | 482.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (4.6 mm I.D. x 250 mm) | End-Fitting: Waters type | 38020-41 | 1 pkg | 509.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (2.0 mm l.D. x 100 mm) | End-Fitting: Waters type | 34367-41 | 1 pkg | 514.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (2.0 mm l.D. x 50 mm) | End-Fitting: Waters type | 05514-01 | 1 pkg | 519.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (4.6 mm l.D. x 75 mm) | End-Fitting: Waters type | 08758-31 | 1 pkg | 519.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (4.6 mm l.D. x 100 mm) | End-Fitting: Waters type | 38067-51 | 1 pkg | 519.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (1.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 02896-01 | 1 pkg | 519.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (2.0 mm I.D. x 100 mm) | End-Fitting: Waters type | 05597-31 | 1 pkg | 541.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (2.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 38025-91 | 1 pkg | 541.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (3.0 mm I.D. x 100 mm) | End-Fitting: Waters type | 05458-51 | 1 pkg | 541.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (3.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 34245-31 | 1 pkg | 541.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (2.0 mm l.D. x 150 mm) | End-Fitting: Waters type | 08723-71 | 1 pkg | 568.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (4.6 mm l.D. x 150 mm) | End-Fitting: Waters type | 04785-91 | 1 pkg | 568.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (2.0 mm I.D. x 250 mm) | End-Fitting: Waters type | 05761-61 | 1 pkg | 594.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (3.0 mm I.D. x 250 mm) | End-Fitting: Waters type | 34254-11 | 1 pkg | 594.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (2.0 mm I.D. x 30 mm) | End-Fitting: Waters type | 11379-01 | 1 pkg | 610.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (2.0 mm I.D. x 50 mm) | End-Fitting: Waters type | 08994-31 | 1 pkg | 610.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (2.0 mm I.D. x 75 mm) | End-Fitting: Waters type | 08995-21 | 1 pkg | 610.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (2.0 mm I.D. x 100 mm) | End-Fitting: Waters type | 08996-11 | 1 pkg | 610.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (3.0 mm I.D. x 50 mm) | End-Fitting: Waters type | 08997-01 | 1 pkg | 610.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (3.0 mm I.D. x 75 mm) | End-Fitting: Waters type | 08998-91 | 1 pkg | 610.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (3.0 mm I.D. x 100 mm) | End-Fitting: Waters type | 08999-81 | 1 pkg | 610.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (6.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 38021-31 | 1 pkg | 664.00 | Buy |
| COSMOSIL 3C18-MS-II Packed Column (2.0 mm l.D. x 250 mm) | End-Fitting: Waters type | 09995-91 | 1 pkg | 696.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (10.0 mm I.D. x 50 mm) | End-Fitting: Waters type | 05789-21 | 1 pkg | 711.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (6.0 mm I.D. x 250 mm) | End-Fitting: Waters type | 38022-21 | 1 pkg | 728.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (1.0 mm I.D. x 50 mm) | End-Fitting: Waters type | 12647-51 | 1 pkg | 733.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (1.0 mm I.D. x 100 mm) | End-Fitting: Waters type | 07594-01 | 1 pkg | 733.00 | Buy |
| COSMOSIL 2.5C18-MS-II Packed Column (1.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 07603-71 | 1 pkg | 733.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (10.0 mm I.D. x 100 mm) | End-Fitting: Waters type | 09479-61 | 1 pkg | 856.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (10.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 34355-91 | 1 pkg | 963.00 | Buy |
Guard Column / Guard Cartridge
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 5C18-MS-II Guard Column (20.0 mm I.D. x 20 mm) | End-Fitting: Waters type | 05790-81 | 1 pkg | 990.00 | Buy |
| COSMOSIL 15C18-MS-II Guard Column (20.0 mm l.D. x 50 mm) | End-Fitting: Waters type | 34524-71 | 1 pkg | 1,070.00 | Buy |
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 5C18-MS-II Packed Column (10.0 mm I.D. x 250 mm) | End-Fitting: Waters type | 38023-11 | 1 pkg | 1,247.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (3 Lots Set) (4.6 mm I.D. x 150 mm) | End-Fitting: Waters type | 09397-73 | 3 pkg | 1,408.00 | Buy |
Guard Column / Guard Cartridge
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 5C18-MS-II Guard Column (20.0 mm I.D. x 50 mm) | End-Fitting: Waters type | 34371-71 | 1 pkg | 1,504.00 | Buy |
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 5C18-MS-II Packed Column (20.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 08578-91 | 1 pkg | 1,926.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (20.0 mm I.D. x 100 mm) | End-Fitting: Waters type | 16580-91 | 1 pkg | 2,007.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (20.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 05091-41 | 1 pkg | 2,114.00 | Buy |
Guard Column / Guard Cartridge
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 15C18-MS-II Guard Column (28.0 mm l.D. x 50 mm) | End-Fitting: Waters type | 05885-51 | 1 pkg | 2,349.00 | Buy |
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 5C18-MS-II Packed Column (20.0 mm I.D. x 250 mm) | End-Fitting: Waters type | 38024-01 | 1 pkg | 2,686.00 | Buy |
Guard Column / Guard Cartridge
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 5C18-MS-II Guard Column (28.0 mm I.D. x 50 mm) | End-Fitting: Waters type | 34347-01 | 1 pkg | 2,804.00 | Buy |
| COSMOSIL 15C18-MS-II Guard Column (50.0 mm l.D. x 50 mm) | End-Fitting: Waters type | 34527-41 | 1 pkg | 4,045.00 | Buy |
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL 5C18-MS-II Packed Column (28.0 mm I.D. x 100 mm) | End-Fitting: Waters type | 16582-71 | 1 pkg | 4,601.00 | Buy |
| COSMOSIL 15C18-MS-II Packed Column (28.0 mm l.D. x 250 mm) | End-Fitting: Waters type | 34525-61 | 1 pkg | 4,783.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (28.0 mm I.D. x 150 mm) | End-Fitting: Waters type | 16583-61 | 1 pkg | 4,815.00 | Buy |
| COSMOSIL 5C18-MS-II Packed Column (28.0 mm I.D. x 250 mm) | End-Fitting: Waters type | 05760-71 | 1 pkg | 5,650.00 | Buy |
| COSMOSIL 15C18-MS-II Packed Column (50.0 mm l.D. x 250 mm) | End-Fitting: Waters type | 05886-41 | 1 pkg | 7,938.00 | Buy |
| COSMOSIL 15C18-MS-II Packed Column (50.0 mm l.D. x 500 mm) | End-Fitting: Waters type | 34531-71 | 1 pkg | 15,040.00 | Buy |
HPLC Accessories
| Product | Description | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| COSMOSIL Guard Cartridge Holder (4.6 mm I.D.) **Discontinued** | End-Fitting: Waters type | 38009-79 | 1 pkg | - | Inquire |
** Guard cartridges require a guard cartridge holder.
** #38009-79 has been discontinued. Alternative product is COSMOSIL Direct Cartridge Holder (#19989-71).