Nerve Organoid™ A-Chip / B-Chip
3D Nerve on a Chip / Starting the Neurorevolution
Jiksak Bioengineering develops research tools and treatments for neurological diseases, with a focus on peripheral nerve disorders. Jiksak means ”axon” in Japanese and our technology revolves around the axon.
Our Core Technologies
Nerve Organoids™
Nerve Organoids™ consist of iPS-derived nerves in a microfluidics device. The nerves formed are very similar to in vivo nerves, with long axons extending from the cell body. Nerve Organoids are used for drug screening and mechanistic studies to discover genes underlying neurological diseases. See our papers for research applications of this technology!
Nerve Organoid™ features
- Structurally separate neural cell body and axon bundle for ease of whole organoid, cellular soma, or acellular axon bundle analyses
- Bundled axons, morphologically analogous to in vivo
- Robust enough to be manipulated with forceps
- Suitable for long term culture
- Generated from differentiated human iPS cells; reproducible and highly consistent
Nerve Organoid™ Research Products
Nerve Organoid™ A-Chip
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A-Chip conists sof 2 wells connected by a microchannel. iPSC-derived neuronal spheres are seeded into the smaller well and axons grow into the microchannel. After culturing for several weeks, the axons will self-organize into a bundle and extend into the far well. Cell body and axon bundle can be isolated separately for protein analysis, RNA extraction, and other molecular analyses.
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Nerve Organoid™ B-Chip
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B-Chip consists of 2 wells connected by a microchannel. The 2 wells are separated by a wall, allowing researchers to culture cells in different media in each well. iPSC-derived neuronal spheres are seeded into the smaller well and axons grow into the microchannel. During culture, axons self-organize into a bundle and extend into the far well where they branch out and expand uniformly into growth cones. B-Chips can be used to co-culture target cell types and to induce human synapse formation using our synaptogenic beads. B-chip fits 48 chips into an SBS standard 96-well plate, making it compatible with imaging systems.
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Nerve Organoid™ P-Chip
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P-Chip is our product for academic research, although we sell to non-academic researchers, as well. This product consists of 8 PDMS inseparable chips mounted on a glass slide. Each chip consists of 2 wells connected by a microchannel. Neuronal cells of interest can be seeded into the smaller well to induce axonal growth into the microchannel. After culturing for several weeks, the axons will self-organize into a bundle and extend into the far well.
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Video - Axon elongation of Nerve Organoid
Reference
Ordering Information
| Product | Storage | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|
| Nerve Organoid™ A-chip (cop/cop) | Room Temp. | JKSK_S0001A_1 | 1 chip | 110.00 | Buy |
| Nerve Organoid™ A-chip (cop/cop) | Room Temp. | JKSK_S0001A_8 | 8 chips/plate | 875.00 | Buy |
| Nerve Organoid™ A-chip (PDMS/Glass) | Room Temp. | JKSK_S0002A_1 | 1 chip | 110.00 | Buy |
| Nerve Organoid™ A-chip (PDMS/Glass) | Room Temp. | JKSK_S0002A_8 | 8 chips/plate | 875.00 | Buy |
| Nerve Organoid™ B-chip | Room Temp. | JKSK_S0001B_1 | 1 chip | 110.00 | Buy |
| Nerve Organoid™ B-chip | Room Temp. | JKSK_S0001B_48 | 48 chips/plate | 5,251.00 | Buy |
| A-chip Dummy Chip | Room Temp. | JKSK_S0001AD_1 | 1 unit | 12.00 | Buy |
| A-chip Dummy Chip | Room Temp. | JKSK_S0001AD_5 | 5 units | 42.00 | Buy |
| A-chip Plate Holder | Room Temp. | JKSK_S0001AP | 1 unit | 19.00 | Buy |
| B-chip Dummy Chip | Room Temp. | JKSK_S0001BD_1 | 1 unit | 16.00 | Buy |
| B-chip Dummy Chip | Room Temp. | JKSK_S0001BD_5 | 5 units | 59.00 | Buy |
| B-chip Plate Holder | Room Temp. | JKSK_S0001BP | 1 unit | 19.00 | Buy |
| Nerve Organoid™ P-chip (Stand-alone) | Room Temp. | JKSK_S0001U_SA | 8 chips/plate | 260.00 | Buy |
| Nerve Organoid™ P-chip (PDMS/Glass) | Room Temp. | JKSK_S0001U | 8 chips/plate | 274.00 | Buy |
These products are manufactured by Jiksak Bioengineering, Inc.