Recombinant Human BCL2
B-cell lymphoma 2
| BCL2 is a member of B cell lymphoma 2 (BCL2) family, which are key regulators in intrinsic apoptosis. BCL2 consists of a hydrophobic pocket to which BH3 helixes bind, preventing apoptosis and cell death. Overexpression of BCL2 has been reported in many cancers and the inhibition of BCL2 activity is a promising approach for cancer therapy. |
| Synonym(s): | B-cell lymphoma 2 |
| Molecular Weight : | 24.7 kDa |
| Tag : | C-terminal His Tag |
| Source : | Escherichia Coli. |
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Purity :
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Greater than 95%, as determined by SDS-PAGE
 |
| Concentration : | 0.6 mg/ml |
| Formulation : | 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 2 mM DTT, 10% Glycerol |
| GeneBank Accession # : | P10415, a.a. 1-211 |
| Application : | Inhibitor Screening, binding assays |
| Storage : | Stable for 12 months at -80°C, Avoid freeze/thaw cycles |
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Reference :
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Vogler, M., Adv Med. 2014. 2014:943648.
Hata, A., et al., Cancer Discov. 2015 May;5(5):475-87.
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Downloads
Recombinant Proteins (Brochure)Ordering Information
| Product | Purity | Storage | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|---|
| Recombinant Human BCL2 | 95 % or more (SDS-PAGE) | -80°C | NU03051 | 100 µg | 426.00 | Buy |