Recombinant Human SOS1
Son of Sevenless Homolog 1
| SOS1 is a guanine nucleotide exchange factor (GEF) for RAS proteins, which are membrane associated proteins involved in various signaling pathways. RAS proteins are activated by GEF-facilitated GDP exchange for GTP, and inactivated by GTP hydrolysis. RAS signaling is upregulated in many different cancers, thus making RAS activation via SOS1 interaction a promising target for cancer therapy. |
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Synonym(s):
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Son of Sevenless Homolog 1
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Molecular Weight :
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57.4 kDa
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Tag :
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N-terminal His-Avi-tagged
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Source :
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E. coli
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Purity :
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Greater than 90%, as determined by SDS-PAGE
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Concentration :
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0.6 mg/ml
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Formulation :
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25 mM Tris HCl pH 7.5, 50 mM NaCl, 1 mM DTT
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GeneBank Accession # :
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Q07889, a.a. 564-1049
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Application :
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Inhibitor Screening, Bindling Assays
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Storage :
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Stable for 12 months at -80°C, Avoid freeze/thaw cycles
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Reference :
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Hillig, R.C., et al., Proc Natl Acad Sci U S A. 2019;116(7):2551-2560.
Hodges, T.R., et al., J Med Chem. 2018;61(19):8875-8894.
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Downloads
Recombinant Proteins (Brochure)Ordering Information
| Product | Purity | Storage | Cat.No. | PKG Size | Price | |
|---|---|---|---|---|---|---|
| Recombinant Human SOS1, His-Avi-tagged | 95 % or more (SDS-PAGE) | -80°C | NU03048-1 | 100 µg | 597.00 | Buy |
| Recombinant Human SOS1, His-Avi-tagged | 95 % or more (SDS-PAGE) | -80°C | NU03048-2 | 1 mg | 3,249.00 | Buy |
| Recombinant Human SOS1 (No tag) | 95 % or more (SDS-PAGE) | -80°C | NU03057-1 | 100 µg | 597.00 | Buy |
| Recombinant Human SOS1 (No tag) | 95 % or more (SDS-PAGE) | -80°C | NU03057-2 | 1 mg | 2,843.00 | Buy |